A Neutral State, calm delight or at “peace” when learning under stress, of equanimity of the structures and interacting areas of the limbic system are involved in learning such as motivation/meaning (Atonement- Will), emotion (Attunement), and memory (Autonomy). The limbic system is where the subcortical structures meet the cerebral cortex. … The limbic system also interacts with the basal ganglia. Also, the need to avoid insensitivity.

Yes, I do believe the disconnect for families, students, and schools and the neurodiverse in general. It’s in the Spiritual Development part of Nerupedagogy, where the disconnect happens in these domains such as: (intellectual) what is right, (moral) what is good, and (imaginative) what is best, His His Divine Will for us and others by in and upon design, plan, and purpose!!!

  • RAS- memory (Autonomy)- ACC part of RAS what is judged “right or wrong”
  • PONS- emotion (Attunement)- HPA part of RAS, what is judged “good or bad”
  • Thymus- motivation/meaning (Atonement- Will and Adaptability)- no judgment just “listened” and tried or did your best, nothing done in vain .

*In a downward function- leading to chaos, non-trusting one’s own mind!!

INTELLECTUAL- what is right, memory (RAS-ACC & HPA)

Pleading Disparagement- expression of a low opinion of someone’s thoughts, ideas, & feelings!! Every cell in your body holds hundreds of pages of information on all levels of your being: physically, emotionally, mentally, and spiritually. Cellular memory is a theory that the body’s cells retain memories independently of the brain. The RAS triangle of well-being—how to promote a healthy flow between your mind, brain, and relationships in a specific way such as Autonomy=Resilience, Attitude, and Focus!

MORAL- what is good, emotion (PONS)

Neuroplasticity is the capacity of nerve cells to biologically adapt to circumstances, to change their connections and behavior in response to new information, sensory stimulation, development, damage, or dysfunction. Mindsight, a skill we can all develop to break free from mental patterns that get in the way of living our lives to the fullest; A practical definition of the mind—distilled from a dozen scientific fields; PONS & The RAS promotes a healthy flow between your mind, brain, and relationships in a specific way such as Attunement=Resilience, Attitude, and Attention!

IMAGINATIVE- what is best In God’s Will, atonement (THYMUS)

Self-directed neuroplasticity and atonement, then, is the ability for the brain to change itself depending on how you direct your thoughts and attention. The THYMUS is the “self-directed” piece refers to your ability to intentionally shape your brain by using it in a specific way such as Autonomy & Attunement= Adaptability (3 A’s)! Meaning, the “whole person”, becoming willing to adapt to Him and allowing him into All consequence made by our own will and choices. Because, this trust will let us know our own truths that basically-We Are Free from the old covet, Sin Laws and Can Come to realize the new covet, Spiritual Laws (water, blood, and Spirit has atoned for us through His resurrection).

Disposition of Genetic Proponents- Genetic Etiology

In broad terms, the findings showed “significant genetic overlap” between anxiety and conditions including PTSD and depression that frequently co-occur with anxiety. This fact, the researchers said, “provides biological evidence that this known clinical comorbidity is due at least in part to shared genetic etiology [causation].” The team found strong positive correlations genetically between participants with recent anxiety symptoms and depressive symptoms and/or neuroticism.

In the portion of the combined sample that is of European ancestry, the strongest GWAS correlation with anxiety was a gene called SATB1, which is thought to influence the activity (“expression”) of multiple other genes involved in neuronal development. One such “influenced” gene is called CRH, which encodes the Corticotropin Releasing Hormone, a protein that plays a central role in the operation of the body’s HPA axis, the linked system in which the hypothalamus, pituitary, and adrenal glands modulate stress and the fear/anxiety response. The protein product of a gene called CRHR1, the researchers note, has been a proposed treatment target for anxiety and stress-related disorders. Retrieved from https:// www.bbrfoundation.org/content/largest- genome-study-date-anxiety-reveals-new-risk- variants-and-suggests-possible-biological.

Epigenetic modulators thus serve to transduce signals from environmental agents, injury, inflammation, aging and other cellular stressors towards modifiers to alter the chromatin states of tumor suppressors or oncogenes and to promote epigenetic flexibility and the acquisition of stem-like features early during:

  • Epigenetic mechanisms form a layer of control within a cell that regulates gene expression and silencing. …
  • Three different epigenetic mechanisms have been identified: DNA methylation, histone modification, and non-coding RNA (ncRNA)- associated gene silencing (“turning off dyslexia”).

“Cells are continuously dying in our body due to infections, cell turnover, developmental processes, and other extrinsic stress…”: In these chromosomes…most present in neurodiversity; we are needing to examine cell health (avoid cytotoxicity) such as:

17 (cell gene– lNF1 provided by HGNC also ACTL6A ) Remember- meaning- knowledge (RAS- see also 11 below/ARAS-THYMUS, & PONS, RAS/GUT,), Engagement with the learning task

22 (connection gene– COMT 22 provided by HGNC ) Recall- motivation- wisdom (Pons), Strategies to process that information

11 (neuronal survival cell gene– DRD2 provided by HGNC ) Recognize- meaning & motivation- understanding (see 17 also ARAS//Thymus/ Testes), Recognition of the information to be learned

A multidisciplinary team at the University of Illinois Urbana-Champaign has devised a new approach to 3D imaging that captures DNA methylation, a key epigenetic change associated with learning in the brain.

The scientists say their proof-of-concept study in pigs will easily translate to humans, as the new method relies on standard MRI technology and biological markers already in use in human medicine. Retrieved from: https:// neurosciencenews-com.cdn.ampproject.org/c/s/ neurosciencenews.com/brain-epigenetics- mri-20118/amp/? fbclid=IwAR3EyW79zJCjerjh1k1jN0ND- LBM2So4O8343qt51hcWFqKSD_6ygr02gWQ

Think about mitochondria and cell health? Also, on a cellular level, think about the Epigenetics Modulators?

Spiritual Mindsight w/

Self Directed Neuroplasticity & Atonement

Translates To Positive Epigenetic Signatures

Intercellular Interactions For Gene Expression

Signalling pathways include the network of biomolecules that serve to transmit signals and induce cellular responses. Post-translational modification of proteins is the most common way signals are propagated. See thymus discussion below, to learn more about the intercellular signalling pathways that has become a common analysis performed across diverse disciplines. (Retrieved from Cell death: From its Induction to the Removal of Dying Cells! https://www.frontiersin.org/research- topics/27626; https:// www.ncbi.nlm.nih.gov/books/ NBK532999/; https://www.nature.com/ articles/s41576-020-00292-x].

This study reports an overlap between genetic architecture and co-morbid mental health diagnosis. Researchers found 70% of the genetic signals associated with schizophrenia were also linked to bipolar disorder. Anorexia and OCD have a strong, shared genetic architecture. As well, More than half of people diagnosed with one psychiatric disorder will be diagnosed with a second or third in their lifetime. About a third have four or more. [Retrieved from https:// neurosciencenews.com/comorbid- mental-health-genetics-20557/].

“Moreover, numerical and functional deficiencies and phenotypic alterations of CD56+ immune cells have been reported in patients with various infectious, autoimmune or malignant diseases (Table 1).” [Retrieved from https:// www.frontiersin.org/articles/10.3389/ fimmu.2017.00892/full].

This study identified an autoantibody that appears to cause schizophrenia in some individuals. The findings add to the growing body of evidence that schizophrenia could have an autoimmune component. The mice with the patient autoantibodies had cognitive impairment and changes in their regulation of the startle reflex, which are both seen in other animal models of schizophrenia. [Retrieved from https:// neurosciencenews.com/autoimmune- schziophrenia-20754/].

Cellular Senescence in Learning Disabilities and Neurodegenerative Disorders

Although several factors can induce senescence, DNA damage, oxidative stress, neuroinflammation, and altered proteostasis have been shown to play a role in its onset. (Retrieved from Cellular Senescence in Neurodegenerative Diseases https:// www.frontiersin.org/article/10.3389/ fncel.2020.00016; https:// downloads.hindawi.com/journals/ omcl/2017/7280690.pdf; https:// www.sciencedaily.com/ releases/2020/01/200129174540.htm). As well, natural ways of deducing neuroinflamation such as Turmeric, Ginkgo biloba, Cayenne, Ginger root & Gongjin-dan.

A slew of 17 studies reveals the first comprehensive list of all cell types in the primary motor complex, offering “a starting point for tracing cellular networks to understand how they control our body and mind and how they are disrupted in mental and physical disorders,” reports ScienceDaily. From the report: The 17 studies, appearing online Oct. 6 in the journal Nature, are the result of five years of work by a huge consortium of researchers supported by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative to identify the myriad of different cell types in one portion of the brain. It is the first step in a long-term project to generate an atlas of the entire brain to help understand how the neural networks in our head control our body and mind and how they are disrupted in cases of mental and physical problems. While researchers have discovered numerous cell types in the brain, this atlas of all cell types in one area — the primary

— is the first comprehensive list and a starting point for tracing cellular networks to understand how they control our body and mind and how they are disrupted in mental and physical disorders. (Retrieved from https:// science.slashdot.org/story/21/10/08/223218/ neuroscientists-roll-out-first-comprehensive- atlas-of-brain-cells; https://www.nature.com/ articles/s41586-021-03950-0).

Three Potential Mechanisms of Transcranial Photobiomodulation (tPBM):

First, by direct stimulation, where photobiomodulation is applied directly on the distressed neurons themselves, activates mitochondrial function that then increases both adenosine triphosphate energy and the expression of stimulatory and/or protective genes.

Second, by indirect stimulation, where photobiomodulation triggers recruitment of a “middle man”, such as cells of the immune and/ or stem cell systems. These activated cells may swarm to the region of distressed neurons and helps them survive and function, by potentially increasing the expression of anti-inflammatory cytokines while decreasing the pro-inflammatory ones.

Third, rather than acting on the distressed neurons through either a direct or indirect stimulation as described above, photobiomodulation may act on other brain regions, for example motor cortex, that then stimulate the neural networks that underpin the behavioural improvements. [Retrieved from https://www.nrronline.org/article.asp? issn=1673-5374;year=2018;volume=13;issue=1 0;spage=1738;epage=1740;aulast=Hamilton].

A very important study shows acute stress as a result of childhood maltreatment to accelerated early maturation of the immune system. Acute psychosocial stress states stimulate the secretion of an antibody type protein that is decisive in the first immune defense against infection, but only after puberty. However, children with a history of maltreatment present a similar response to that of adolescents, which suggests there is an early maturation of the immune system in these cases. [Retrieved from https:// www.sciencedirect.com/science/article/pii/ S0889159122001076; https:// neurosciencenews.com/immune-system-child- maltreatment-20586/].

  1. *10- Thymus, see brain and testes association HERE. TBATA provided by HGNC gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis [a class of large neurons present in the peripheral nervous system below] and synaptic plasticity. As well, the energy cycles which are known as circadian rhythms, which were popularized by Nobel Prize-winning researchers Jeffrey Hall, Michael Rosbash, and Michael Young. They highlighted that every cell in the body is set to follow this biological clock which determines your sleep, appetite, hormone releases, and energy levels. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants (see Thymus below). “The circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms, from prokaryotes to humans. Identification of clock genes has allowed us to study the molecular bases for circadian behaviors and temporal physiological processes such as hormonal secretion, and has prompted the idea that molecular clocks reside not only in a central pacemaker, the suprachiasmatic nuclei (SCN) of hypothalamus in mammals, but also in peripheral tissues, even in immortalized cells.” Furthermore …(See RAS, Pons, Thymus below, and see brain and testes association HERE-Retrieved from Thymus Function and Aging: A Focus on Thymic Epithelial Cells https:// http://www.frontiersin.org/research-topics/24158 https:// pubmed.ncbi.nlm.nih.gov/15834108/; https://link.springer.com/ article/10.1186/1471-2199-5-18).

‘A man’s mind plans his way [as he journeys through life], But the Lord directs his steps and establishes them [anchor or standby]. ‘ Proverbs 16:9 AMP

Published by Tricia Cook, MEd., Online Dyslexia and Behavioral Interventionist, RSP, AA O-G Tutor & Montessorian

My interest is in helping parents and teachers to understand learning and behavioral challenges and to love learning again. I graduated from Auburn in ECE in 1998. I have been a Montessori teacher here in Birmingham for almost 12 years and have lived in Birmingham for the past 19 years. As an early childhood teacher, I want continue to grow and develop as a constant learner. In 2012, I graduated from Secondary Education with a P-12 Reading Specialist certification the University of Alabama. As a Reading Specialist, I train on diversity and literacy development; I have a specialized knowledge of assessment and diagnosis that is vital for developing, implementing, and evaluating your literacy and neurodiversity behavioral, character development programing. Also, I have varying experiences designing instruction and environments for Montessori and Non-Montessori (OSR-Pre-K) environments. Therefore, I can consult for any environment or setting! In 2013, I attained my highly qualified status in ECE and Reading. In 2013, I also got my Orton-Gillingham AA tutor certification. I currently tutor full-time along with consulting. I have actually been tutoring since 2003. Along with other independent tutoring/interventionist experiences, I have brought dozens of students from an emergent to an advanced reading level! In addition to tutoring, I have provided the reading strengths and needs of my students and share that information to classroom teachers, parents, specialized teachers, and other stakeholders.  Lastly, I have also been a trainer/presenter, since 2008 and really enjoy this aspect of my career. As an experienced trainer, I have trained on many topics including: literacy (the five components), classroom management, positive discipline, diversity character development, Montessori Philosophy, policies and procedures, child development, and Alabama's Pre-k. Take note: Schools and families are desperately looking for an alternative type of affordable multi-sensory, hands-on, and interesting instruction. Currently, I am training and interested in writing on the following topics: A Comparison of Pre-K to Kindergarten; Adolescent Literacy (7th+); Assessment; Developing Readers; Children’s Literature; Classroom Management Techniques; Comprehension; Montessori Philosophy; Environmental Print & Early Writing; Family Attachment; Language and Literacy; Outdoor Classroom; Poetry Writing (7th+); Positive Guidance; Fine-motor Development; Cursive Writing; Creative Writing; Comprehension: Study Skills/Test Taking Strategies; Morphology; Phonics Instruction; Diversity Education; Neurodiversity Education; HandWriting; Reading Strategies; Best Practices P-12. Thank you, Tricia Cook, MEd., RSP, AOG; https://linktr.ee/tcooktutor

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