Epigenetics comes to Life: Neurodevelopmental disorders (NDDs) encompass a broad group of conditions characterized by alterations in the development of the central nervous system (CNS), resulting in varying degrees of cognitive and/or behavioral symptoms. Several conditions are grouped under the diagnosis of NDD, including intellectual disability (ID), learning disorders, communication disorders, motor disorders, attention deficit hyperactivity disorder (ADHD), autism spectrum condition (ASC), epileptic encephalopathies (EE), and schizophrenia (SZ) [1, 2]. In the “Journal Nature Neuroscience”: Intelligence ‘Networks’ Discovered In Brain For The First Time, 2015-“Remarkably, they found that some of the same genes [M1 & M3] HERE that influence human intelligence in healthy people were also the same genes that cause impaired cognitive ability and epilepsy when mutated.” “Also, studies show that autistic people have a 20% risk of having epilepsy and that people with epilepsy have a 20% chance of being autistic. The reason for this may be that the effects of epilepsy and autism spectrum condition (ASC) on brain structure and function overlap. Chromosome 12-GRIN2B The NMDA receptors mediate a slow -permeable component of excitatory synaptic transmission in the central nervous system. The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum condition, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. Autism spectrum condition (ASC) and dyslexia are both neurodevelopmental disorders with high prevalence in children. These two disorders share common genetic risks remain elusive. DOCK4 (dedicator for cytokinesis 4), a guanine nucleotide exchange factor (GEF) for the small GTPase Rac1, is one of few genes that are associated with both autism spectrum condition (ASC) and dyslexia. Dock4 is important for neuronal development and social behaviors [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488083/; https://www.frontiersin.org/articles/10.3389/fncel.2019.00577/full]
What is the Interoceptive System? Having trouble with this sense can also make self-regulation a challenge because of physiological processes related to affective feeling. The interoceptive system [also] has special nerve receptors which are located throughout our bodies including internal organs, bones, muscles, and skin. These receptors send information to the brain. The brain interprets this information and uses it to tell us how we feel. The interoceptive system helps our bodies stay in a state of optimal balance, which is known as homeostasis. [Retrieved from https://occupationaltherapy.com.au/interoception]. Especially, it’s hard for those with Interoceptive Discrimination Disorder (IDD), which is a form of Sensory Processing Disorder (SPD), it is very difficult to distinguish internal feelings from external ones. [Retrieved from http://sinetwork.org/the-other-senses-interoception/]. Note: A study found impaired functional connectivity and autistic-like behaviors in CX3CR1−/− mice lacking responsive microglia (Zhan and others 2014), for example, though this could be due to two reasons: a transient decreased microglial density in postnatal development, or the fractalkine signaling pathway being responsible for the tagging of synapses.
Also, a new study expressed by microglia—the immune cells of the central nervous system—TAMs perform bona fide immune-related roles as regulation of inflammation and cytokine secretion both in health and in disease such as Alzheimer’s and Parkinson’s disease, ischemia, and multiple sclerosis. Likewise, TAM receptor MERTK expression is enriched in the central nervous system and in resident innate immune cells where it regulates numerous functions that support brain plasticity. [Retrieved from https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/neuroimmune-brain-plasticity-19663/amp/?fbclid=IwAR2-b73FidTuEOXEratUhsXrvKD9Be9PWOVfCRsYTAG8IDColpka5Lm3EpM].
Devotion and the work need for self-abandonment- controls the lymphatic system. 639 Hz. Connection- Love and Unity. YAM- creates harmony and harmonious relationships along with brining understanding, communication, tolerance, and love. `Also, it brings inner peace. Essential Meaning of harmony1: the combination of different musical notes played or sung at the same time to produce a pleasing sound She taught him how to sing harmony. [=how to sing notes that combined with other notes in a pleasing way] a song with complicated harmonies and rhythms 2: a pleasing combination or arrangement of different things a harmony of flavors/colors Full Definition of harmony1a: the combination of simultaneous musical notes in a chord She taught him how to sing harmony. b: the structure of music with respect to the composition and progression of chords a song with complicated harmonies and rhythms c: the science of the structure, relation, and progression of chords 2a: pleasing arrangement of parts : congruence a painting exhibiting harmony of color and line b: agreement, accord when a woman’s desires are in harmony with those of her husband c: internal calm : tranquility a period of relative harmony 3: an interweaving of different accounts into a single narrative b: a systematic arrangement of parallel literary passages (as of the Gospels) for the purpose of showing agreement or harmony 4 archaic: tuneful sound : melody ENCOURAGES THE CELLS TO COMMUNICATE- With Astral Plane to Promote Personal & Spiritual Development:See NURTURE THEIR NATURE by Tricia Cook “Come to me, all you who are weary and burdened, and I will give you rest. Matthew 11:28 https://www.bible.com/en-GB/bible/111/MAT.11.28.NIV
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