Cook’s FSD Dysregulation: Functional system regulation using a spiritual growth-oriented learning model. Nurture Their Nature Newsletter. T. Cook, 2023 Feb.: V.1 A.5
Emotions such as anger and shame can trigger signaling pathways within the brain and body, leading to a range of physiological and psychological responses [a]. These emotions can activate the sympathetic nervous system, which prepares the body for a “fight or flight” response, leading to an increase in heart rate, blood pressure, and adrenaline release . The parasympathetic nervous system has an opposite effect and is responsible for the “rest and digest” response, which helps to promote relaxation and restore the body to a calm, balanced state after periods of stress.
When the parasympathetic nervous system is activated, heart rate and breathing rate slow down, which can lead to feelings of relaxation and calmness. However, excessive activation of the parasympathetic nervous system can also lead to lethargy and a feeling of “shut down.” This can sometimes occur in students who may experience high levels of stress and anxiety, leading to chronic activation of the sympathetic nervous system. When this happens, the parasympathetic nervous system may become overactive in an attempt to restore balance, leading to feelings of lethargy, fatigue, and a lack of motivation .
It is critical to find a balance between the sympathetic and parasympathetic nervous systems in order to maintain optimal health and well-being. Practices such as mindfulness meditation, yoga, and deep breathing exercises can help to promote this balance by reducing chronic stress and promoting relaxation. Additionally, getting enough rest and practicing healthy sleep hygiene can also help to maintain a healthy balance between the sympathetic and parasympathetic nervous systems . Chronic activation of the para/sympathetic nervous system can have negative effects on health, leading to an increased risk of conditions such as cardiovascular disease and depression .
Therefore, it is essential to regulate and manage emotions to maintain optimal health and well-being.
Epigenetic modulators can potentially modulate gene expression related to emotions and stress responses, affecting the functioning of the limbic system. Some research suggests that certain epigenetic modifications may be associated with increased vulnerability to stress and mood disorders [7, 5]. Epigenetic modulators are compounds or substances that can modify the activity of genes without altering the DNA sequence. Epigenetic modifications, such as DNA methylation and histone modification, play a crucial role in regulating gene expression. Therefore, modulating these modifications can have significant effects on gene activity and cellular function .
Regarding the limbic system, equanimity, or a state of calm and balance, can have a positive impact on the function of the limbic system. This is especially true in areas related to learning, motivation, emotion, and memory. High-stress emotional states, on the other hand, can disrupt the limbic system’s function and lead to maladaptive behaviors and emotions. Therefore, techniques and interventions that promote equanimity and reduce stress can be helpful in maintaining optimal limbic system function .
Signaling pathways are critical for the transmission of signals within and between cells, allowing cells to sense and respond to their environment. Post-translational modifications, which are chemical modifications that occur after a protein is synthesized, play a crucial role in regulating signaling pathways . For example, phosphorylation, a common post-translational modification, can activate or inactivate proteins involved in signaling pathways by adding or removing a phosphate group. Other post-translational modifications, such as acetylation, methylation, and ubiquitination, can also modulate protein activity and function within signaling pathways .
The thymus is an organ involved in the development of T cells, a type of white blood cell that plays a critical role in the immune response. Intercellular signaling pathways are essential for proper thymus development and function, as signals between different cell types are necessary for the differentiation and maturation of T cells .
Cook’s Call For More Research
Studying signaling pathways is a common analysis performed across diverse disciplines, including cell biology, biochemistry, pharmacology, and disease research. By understanding how signals are transmitted and regulated, researchers can develop new therapies for various diseases and gain insights into fundamental biological processes . Therefore, more research into maintaining a state of equanimity and balance within the limbic system can have a positive impact on emotional regulation and stress management. This needs to be addressed for students of neurodiversity including practices such as mindfulness, prayer, praise and worship, meditation, exercise, and stress reduction techniques [b].
There are several natural and synthetic compounds that have been identified as epigenetic modulators, as well as dietary compounds like resveratrol and curcumin . Resveratrol is found in grapes, wine, grape juice, peanuts, cocoa, and berries. Vaccinium species, including blueberries, bilberries, and cranberries. Turmeric powder and root can be added to many foods, such as curries, sauces, salad dressings, rice, potatoes and meats. These compounds have therapeutic potential for various diseases, including cancer, neurological disorders, and autoimmune diseases.
Several holistic and spiritual practices can help to promote equanimity and lessen the negative effects of chronic stress on the body and mind. By reducing the activation of stress-related signaling pathways, these practices can potentially improve mental and physical health. Certain practices such as mindfulness meditation, yoga, and deep breathing exercises can help to activate the parasympathetic nervous system, resulting in relaxation. These will reduce the negative effects of chronic stress on the body and mind.
These practices can help to balance the sympathetic and parasympathetic nervous systems, promoting overall health and well-being. Spiritual practices such as prayer, meditation, and community involvement can provide a sense of connection and meaning, which can alleviate stress and improve overall well-being. By promoting equanimity and reducing stress-related signaling pathways, these practices can potentially improve mental and physical health, and enhance overall quality of life.
For more information: http://www.myelbert.com © 2018, In-Text Citation: [a] Cook T. Cook’s FSD Dysregulation: Functional System Regulation Using a Spiritual Growth-Oriented Learning Model; Feb; 2023; myelbert. [b] N T Nature – Helping Those with a Neurodiversity Enjoy Learning Again (Updated) Part I. Scribd, Methodology is shown in the outer columns, resultant data sets in the middle columns, and model systems in the center. © 2003 Nature Publishing Group.
- Gameiro J, Nagib P, Verinaud L. The thymus microenvironment in regulating thymocyte differentiation. Cell Adh Migr. 2010 Jul-Sep;4(3):382-90. doi: 10.4161/cam.4.3.11789. Epub 2010 Jul 15. PMID: 20418658; PMCID: PMC2958614.
- Garfinkel, Sarah N, et al. “Anger in Brain and Body: The Neural and Physiological Perturbation of Decision-Making by Emotion.” Social Cognitive and Affective Neuroscience, U.S. National Library of Medicine, 1 Jan. 2016,
- Handy DE, Castro R, Loscalzo J. Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation. 2011 May 17;123(19):2145-56. doi: 10.1161/CIRCULATIONAHA.110.956839. PMID: 21576679; PMCID: PMC3107542.
- “How the Parasympathetic Nervous System Can Lower Stress.” Hospital for Special Surgery, https://www.hss.edu/article_parasympathetic-nervous-system.asp.
- Mariotti A. The effects of chronic stress on health: new insights into the molecular mechanisms of brain-body communication. Future Sci OA. 2015 Nov 1;1(3):FSO23. doi: 10.4155/fso.15.21. PMID: 28031896; PMCID: PMC5137920.
- Matosin N, Cruceanu C, Binder EB. Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress. Chronic Stress (Thousand Oaks). 2017 Feb 1;1:2470547017710764. doi: 10.1177/2470547017710764. Epub 2017 Jun 16. PMID: 29503977; PMCID: PMC5831952.
- McGowan PO, Kato T. Epigenetics in mood disorders. Environ Health Prev Med. 2008 Jan;13(1):16-24. doi: 10.1007/s12199-007-0002-0. Epub 2007 Dec 11. PMID: 19568875; PMCID: PMC2698240.
- Ramazi S, Zahiri J. Posttranslational modifications in proteins: resources, tools and prediction methods. Database (Oxford). 2021 Apr 7;2021:baab012. doi: 10.1093/database/baab012. PMID: 33826699; PMCID: PMC8040245.
- Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB. Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr. 2011 May;6(2):93-108. doi: 10.1007/s12263-011-0222-1. Epub 2011 Apr 24. PMID: 21516481; PMCID: PMC3092901.
- Russo, Marc A, et al. “The Physiological Effects of Slow Breathing in the Healthy Human.” Breathe (Sheffield, England), U.S. National Library of Medicine, 1 Dec. 2017,
- Schuman-Olivier Z, Trombka M, Lovas DA, Brewer JA, Vago DR, Gawande R, Dunne JP, Lazar SW, Loucks EB, Fulwiler C. Mindfulness and Behavior Change. Harv Rev Psychiatry. 2020 Nov/Dec;28(6):371-394. doi: 10.1097/HRP.0000000000000277. PMID: 33156156; PMCID: PMC7647439.
- Svoboda KK, Reenstra WR. Approaches to studying cellular signaling: a primer for morphologists. Anat Rec. 2002 Apr 15;269(2):123-39. doi: 10.1002/ar.10074. PMID: 12001220; PMCID: PMC2862383.
- Theillet FX, Smet-Nocca C, Liokatis S, Thongwichian R, Kosten J, Yoon MK, Kriwacki RW, Landrieu I, Lippens G, Selenko P. Cell signaling, post-translational protein modifications and NMR spectroscopy. J Biomol NMR. 2012 Nov;54(3):217-36. doi: 10.1007/s10858-012-9674-x. Epub 2012 Sep 26. PMID: 23011410; PMCID: PMC4939263.