My Elbert: Neurodiversity & Epigenetic Modulators

Epigenetic modulators thus serve to transduce signals from environmental agents, injury, inflammation, aging and other cellular stressors towards modifiers to alter the chromatin states of tumor suppressors or oncogenes and to promote epigenetic flexibility and the acquisition of stem-like features early during:

  • Epigenetic mechanisms form a layer of control within a cell that regulates gene expression and silencing. …
  • Three different epigenetic mechanisms have been identified: DNA methylation, histone modification, and non-coding RNA (ncRNA)-associated gene silencing (“turning off dyslexia”).

“Cells are continuously dying in our body due to infections, cell turnover, developmental processes, and other extrinsic stress…”: In these chromosomes…most present in neurodiversity; we are needing to examine cell health (avoid cytotoxicity) such as:

17  (cell gene– lNF1 provided by HGNC also ACTL6A ) Remember- meaning- knowledge (RAS- see also 11 below/ARAS-THYMUS, & PONS, RAS/GUT,), Engagement with the learning task

22 (connection gene– COMT 22 provided by HGNC ) Recall- motivation- wisdom (Pons), Strategies to process that information

11 (neuronal survival cell gene– DRD2 provided by HGNC ) Recognize- meaning & motivation-understanding (see 17 also ARAS//Thymus/Testes), Recognition of the information to be learned

A multidisciplinary team at the University of Illinois Urbana-Champaign has devised a new approach to 3D imaging that captures DNA methylation, a key epigenetic change associated with learning in the brain.

The scientists say their proof-of-concept study in pigs will easily translate to humans, as the new method relies on standard MRI technology and biological markers already in use in human medicine. Retrieved from: https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/brain-epigenetics-mri-20118/amp/?fbclid=IwAR3EyW79zJCjerjh1k1jN0ND-LBM2So4O8343qt51hcWFqKSD_6ygr02gWQ

Think about mitochondria and cell health? Also, on a cellular level, think about the Epigenetics Modulators?

Spiritual Mindsight w/

Self Directed Neuroplasticity & Atonement

Translates To Positive Epigenetic Signatures

Intercellular Interactions For Gene Expression

Signalling pathways include the network of biomolecules that serve to transmit signals and induce cellular responses. Post-translational modification of proteins is the most common way signals are propagated. See thymus discussion below, to learn more about the intercellular signalling pathways that has become a common analysis performed across diverse disciplines. (Retrieved from Cell death: From its Induction to the Removal of Dying Cells! https://www.frontiersin.org/research-topics/27626; https://www.ncbi.nlm.nih.gov/books/NBK532999/; https://www.nature.com/articles/s41576-020-00292-x].

This study reports an overlap between genetic architecture and co-morbid mental health diagnosis. Researchers found 70% of the genetic signals associated with schizophrenia were also linked to bipolar disorder. Anorexia and OCD have a strong, shared genetic architecture. As well, More than half of people diagnosed with one psychiatric disorder will be diagnosed with a second or third in their lifetime. About a third have four or more. [Retrieved from https://neurosciencenews.com/comorbid-mental-health-genetics-20557/].

“Moreover, numerical and functional deficiencies and phenotypic alterations of CD56+ immune cells have been reported in patients with various infectious, autoimmune or malignant diseases (Table 1).” [Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2017.00892/full].

This study identified an autoantibody that appears to cause schizophrenia in some individuals. The findings add to the growing body of evidence that schizophrenia could have an autoimmune component. The mice with the patient autoantibodies had cognitive impairment and changes in their regulation of the startle reflex, which are both seen in other animal models of schizophrenia. [Retrieved from https://neurosciencenews.com/autoimmune-schziophrenia-20754/].

Cellular Senescence in Learning Disabilities and Neurodegenerative Disorders

Although several factors can induce senescence, DNA damage, oxidative stress, neuroinflammation, and altered proteostasis have been shown to play a role in its onset. (Retrieved from Cellular Senescence in Neurodegenerative Diseases https://www.frontiersin.org/article/10.3389/fncel.2020.00016; https://downloads.hindawi.com/journals/omcl/2017/7280690.pdf; https://www.sciencedaily.com/releases/2020/01/200129174540.htm). As well, natural ways of deducing neuroinflamation such as Turmeric, Ginkgo biloba, Cayenne, Ginger root & Gongjin-dan.

A slew of 17 studies reveals the first comprehensive list of all cell types in the primary motor complex, offering “a starting point for tracing cellular networks to understand how they control our body and mind and how they are disrupted in mental and physical disorders,” reports ScienceDaily. From the report: The 17 studies, appearing online Oct. 6 in the journal Nature, are the result of five years of work by a huge consortium of researchers supported by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative to identify the myriad of different cell types in one portion of the brain. It is the first step in a long-term project to generate an atlas of the entire brain to help understand how the neural networks in our head control our body and mind and how they are disrupted in cases of mental and physical problems. While researchers have discovered numerous cell types in the brain, this atlas of all cell types in one area — the primary

— is the first comprehensive list and a starting point for tracing cellular networks to understand how they control our body and mind and how they are disrupted in mental and physical disorders. (Retrieved from https://science.slashdot.org/story/21/10/08/223218/neuroscientists-roll-out-first-comprehensive-atlas-of-brain-cells; https://www.nature.com/articles/s41586-021-03950-0).

Learn More HERE

Published by Tricia Cook, MEd., Online Dyslexia and Behavioral Interventionist, RSP, AA O-G Tutor & Montessorian

My interest is in helping parents and teachers to understand learning and behavioral challenges and to love learning again. I graduated from Auburn in ECE in 1998. I have been a Montessori teacher here in Birmingham for almost 12 years and have lived in Birmingham for the past 19 years. As an early childhood teacher, I want continue to grow and develop as a constant learner. In 2012, I graduated from Secondary Education with a P-12 Reading Specialist certification the University of Alabama. As a Reading Specialist, I train on diversity and literacy development; I have a specialized knowledge of assessment and diagnosis that is vital for developing, implementing, and evaluating your literacy and neurodiversity behavioral, character development programing. Also, I have varying experiences designing instruction and environments for Montessori and Non-Montessori (OSR-Pre-K) environments. Therefore, I can consult for any environment or setting! In 2013, I attained my highly qualified status in ECE and Reading. In 2013, I also got my Orton-Gillingham AA tutor certification. I currently tutor full-time along with consulting. I have actually been tutoring since 2003. Along with other independent tutoring/interventionist experiences, I have brought dozens of students from an emergent to an advanced reading level! In addition to tutoring, I have provided the reading strengths and needs of my students and share that information to classroom teachers, parents, specialized teachers, and other stakeholders.  Lastly, I have also been a trainer/presenter, since 2008 and really enjoy this aspect of my career. As an experienced trainer, I have trained on many topics including: literacy (the five components), classroom management, positive discipline, diversity character development, Montessori Philosophy, policies and procedures, child development, and Alabama's Pre-k. Take note: Schools and families are desperately looking for an alternative type of affordable multi-sensory, hands-on, and interesting instruction. Currently, I am training and interested in writing on the following topics: A Comparison of Pre-K to Kindergarten; Adolescent Literacy (7th+); Assessment; Developing Readers; Children’s Literature; Classroom Management Techniques; Comprehension; Montessori Philosophy; Environmental Print & Early Writing; Family Attachment; Language and Literacy; Outdoor Classroom; Poetry Writing (7th+); Positive Guidance; Fine-motor Development; Cursive Writing; Creative Writing; Comprehension: Study Skills/Test Taking Strategies; Morphology; Phonics Instruction; Diversity Education; Neurodiversity Education; HandWriting; Reading Strategies; Best Practices P-12. Thank you, Tricia Cook, MEd., RSP, AOG; https://linktr.ee/tcooktutor

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