Where is the vitamin D receptor?
In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13. 11. Like the iNKT cells, there are also fewer CD8αα/TCRαβ precursors in the thymus of VDR-KO animals. Moreover, to complete development CD8αα/TCRαβ cells must travel from the thymus to the gastrointestinal tract where IL-15 induces proliferation and upregulation of CD8αα. Due to decreased levels of IL-15 receptor expression VDR-KO CD8αα/TCRαβ cells proliferate poorly, resulting in a diminished mature CD8αα/TCRαβ population in the VDR-KO gut (Yu et al., 2008; Bruce and Cantorna, 2011; Ooi et al., 2012). These data illustrate that in contrast to conventional T cells, VDR expression is mandatory for development of both iNKT cells and CD8αα/TCRαβ T cells. VDR is expressed in most tissues of the body, and regulates transcription of about 900 genes involved in intestinal and renal transport of calcium and other minerals. In a study by Patel et al. (1995) plasma toxins from uremic patients was shown to bind to the patient’s VDR, thereby disrupting binding of VDR-RXR to DNA resulting in a diminished VDR response. It so appears that post-translational modifications of VDR adjust VDR activity in both health and disease. [Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2013.00148/full]; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789451/],
Bones provide both skeletal scaffolding and space for hematopoiesis in its marrow. Previous work has shown that these functions were tightly regulated by the nervous system. The central and peripheral nervous systems tightly regulate compact bone remodeling, its metabolism, and hematopoietic homeostasis in the bone marrow (BM). Accumulating evidence indicates that the nervous system, which fine-tunes inflammatory responses and alterations in neural functions, may regulate autoimmune diseases. Neural signals also influence the progression of hematological malignancies such as acute and chronic myeloid leukemias. Here, we review the interplay of the nervous system with bone, BM, and immunity, and discuss future challenges to target hematological diseases through modulation of activity of the nervous system. [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119651/]. The lymphatic system consists of lymphatic organs such as bone marrow, the tonsils, the thymus, the spleen, and lymph nodes. All lymphocytes develop in bone marrow from immature cells called stem cells. [Retrieved from https://www.medicalnewstoday.com/articles/285666].
Note: In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13. 11. VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals (See asc, adhd, epilipsry and schzophrinia & Chromosome 12 above).
Similarly, early last year, researchers from institutes in Germany and Greece reported a mechanism in the brain’s outer cortical cells that produces a novel ‘graded’ signal all on its own, one that could provide individual neurons with another way to carry out their logical functions. By measuring the electrical activity in sections of tissue removed during surgery on epileptic patients and analyzing their structure using fluorescent microscopy, the neurologists found individual cells in the cortex used not just the usual sodium ions to ‘fire’, but calcium as well. [Retrieved from https://www.sciencealert.com/a-never-before-seen-type-of-signal-has-been-detected-in-the-human-brain?fbclid=IwAR3sZiK3xsrIVnHirG-RjcIKY9NW5czdUk3iPK8dURZnz-qXaKsXJwE6sDs].
Hyponatremia is not only the most common electrolyte disorder but is also associated with higher infection rate , cardiovascular disease [2, 3], and mortality risk [4, 5]. Central nervous system (CNS) symptoms are the main manifestations of hyponatremia . Think about how dementia cause an electrolyte imbalance? Residents who have very advanced dementia may also develop electrolyte imbalance because their brain no longer reminds their body to drink or accept fluids when offered to them. How is an electrolyte imbalance diagnosed? Electrolyte imbalance is usually diagnosed by blood tests. Does level(s) affect dementia? Several studies reported that chronic hyponatremia resulted in mild cognition impairment (MCI) [7, 8], which in turn was associated with increased risk of progression to dementia  or death . [Retrieved from https://www.ncbihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462431/].
Similarly, think about manganese and neurodegenerative diseases. Manganese [Mn] is an essential ubiquitous trace element required for normal growth, development and cellular homeostasis . Specifically, Mn is important in bone formation, fat and carbohydrate metabolism, blood sugar regulation, and calcium absorption. In humans and animals, Mn functions as a required cofactor of several enzymes necessary for neuronal and glial cell function, as well as enzymes involved in neurotransmitter synthesis and metabolism [2, 3, 4] [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230726/].
NOTE: What surprised researchers was that patients with depression were prone to IBD. Zhang speculates that this discovery may have to do with what is known as the gut-brain axis, a scientifically established connection between the gastrointestinal system and the central nervous system, which consists of the spinal cord and the brain. [Retrieved from https://neurosciencenews.com/ibd-depression-20724/].
Endogenous regeneration in the brain is the ability of cells to engage in the repair and regeneration process. … Another benefit that can be achieved by using endogenous regeneration could be avoiding an immune response from the host. There are therapeutic approaches for boosting thymus function. Likewise, the causes age-related thymic involution have been suggested along with several possible mechanisms identified including blockages of T-cell receptor gene rearrangement, decreased self-peptide MHC molecules, and depletion of T-cell progenitors [Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837659/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750859/;
Note: In the brain, hormones alter or change the production of gene products that participate in synaptic neurotransmission as well as affect the structure of brain cells. As a result, the circuitry of the brain and its capacity for neurotransmission. I give natural and holistic ways to improve your thymic hormone function and cell-mediated immunity… “Although epigenetic modulators that control effector status in Th17 cells have been identified 15, 21, the TF regulators that globally program the capacity of CD4+ T cells to dynamically control their functional identity in response to changing contexts are mostly undefined.” Retrieved from cell gene and https://www.pnas.org/content/115/8/1883 (see HPA & Pineal Body, Pituitary & Adrenal Glands below).
Supplementation with these nutrients has been shown to improve thymic hormone function and cell-mediated immunity such as…Zinc, vitamin B6, and vitamin C are perhaps the most critical. Zinc may be the critical mineral involved in thymus gland function and thymus hormone action. Hematite worn around the neck brings balance to both the etheric body and the physical body. Due to its magnetic nature and our ying-yang energies, it’s nature is to bring us back to equilibrium. Plus, Note: I go much deeper than supplements like neurometric education (read below) to avoid early thymic involution and/or dysfunction, imbalance, etc. …. (Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2020.01745/full; https://www.frontiersin.org/research-topics/11340/new-insights-into-thymic-functions-during-stress-aging-and-in-disease-settings).
magnetic– rTMS is a depression treatment (as well dementia) typically used when other approaches—such as medications—haven’t been effective for a patient. It is estimated that approximately 40 percent of people with major depression do not respond to antidepressants. They found, that by stimulating the dorsolateral pre-frontal cortex, several other regions of the brain were also activated. These other regions are involved in multiple functions—from managing emotional responses to memory and motor control. Again, the participants then underwent another four weeks of rTMS treatment and the team assessed whether the activated regions were associated with patients having fewer symptoms of depression when their treatment ended. Retrieved from https://neurosciencenews.com/rtms-depression-20612/].
*ACE- (aka Anger Enzyme) Angiotensin-converting enzyme (EC 126.96.36.199), is a central component of the renin–angiotensin system (ras), which controls blood pressure by regulating the volume of fluids in the body (See Gut-brain axis and Neurotoxicity). Corticotropin-releasing hormone (see hypothalamus below)- Stress induces the hypothalamic production and release of CRH, which then causes the activation of the CRH receptor (CRHR) type 1 (CRHR-1) in the anterior pituitary (see HPA below) to stimulate ACTH release, as well as proopiomelanocortin (POMC) expression and processing. Rationale: The corticotropin-releasing hormone (CRH) stimulation test has been used as a diagnostic test in both adrenal insufficiency and Cushing syndrome. Glucocorticoids are essential steroid hormones secreted from the adrenal gland in response to stress. (Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819560/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819560/; https://www.frontiersin.org/research-topics/7323/involvement-of-neuro-immune-mechanism-and-brain-gut-axis-in-pathophysiology-of-mood-disorders#articles).
συνάγω (Strong’s #4863 — Verb — sunago — soon-ag’-o ) “to bring together” (sun, “together,” ago, “to bring”), is used in the sense of “bestowing,” or stowing, by the rich man who laid up his goods for himself, Luke 12:17,18 . See ASSEMBLE , COME , GATHER , LEAD , RESORT , TAKE
A growing body of evidence suggests that chronic anger can take a daily toll on your cardiovascular health and immune system. Letting go of the bitterness you feel toward another person can lower your anxiety, which directly impacts both your mental and physical health. Basically, feeling bad is bad for you—especially if those feelings are due to bitter or traumatic memories that frequently to mind unbidden. [Retrieved from https://getpocket.com/explore/item/forgiving-people-is-good-for-your-health-here-s-how-to-do-it?utm_source=pocket-newtab]. Note: If something confounds you, as well could make someone angry, it makes you feel surprised and confused, often because it does not meet your predefined expectations (perceptions).
*Aside: An estimated 6.2 million Americans age 65 and older are living with Alzheimer’s dementia in 2021. The number of people with dementia is expected to increase to 152 million by 2050. My dad being one of those. The fundamental principle of Montessori approach is to value a patients’ naturally inquisitive and improving symptoms of dementia to foster learning in an intuitive and natural way.
In Alzheimer’s disease, tau and another protein called amyloid-beta build up into tangles and plaques—known collectively as aggregates.
Interesting Research- Dementia, those with memory loss, they did have faster thinning of the entorhinal cortex due to amyloid level as well as brain shrinkage of the hippocampus. Relevantly, the Wnt pathway has been recognized as critical for the central nervous system development, several Wnt components retain their expression in the adult brain, including the hippocampus, and have proven to be fundamental in both the development and function of synapses (Inestrosa and Arenas, 2010; Inestrosa and Varela-Nallar, 2015). Altogether, these findings strongly suggest that Wnt signaling might be down-regulated during aging, leading to increased vulnerability of the neural network and increasing the risk for the onset and progression of age-related pathologies, such as AD. Wnt inhibitors, including the secreted-frizzled-related protein 1 and 2 (SFRP-1 and SFRP-2) and Dickkopf-1 (Dkk-1), all them antagonists at the cell surface. As a result, mice deficient in Dkk-1 exhibit enhanced spatial working memory and memory consolidation and also show improvements in affective behavior (Caricasole et al., 2003, 2004) [Retrieved from Scienmag. “SCIENMAG.” What Comes First, Beta-Amyloid Plaques or Thinking and Memory Problems?, apple.news/A0bfYT-YLR2u8kRquMsjKRA; Scienmag. “SCIENMAG.” What Comes First, Beta-Amyloid Plaques or Thinking and Memory Problems?, apple.news/A0bfYT-YLR2u8kRquMsjKRA?fbclid=IwAR2; https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf; https://www.frontiersin.org/articles/10.3389/fpsyt.2021.737270/full?fbclid=IwAR1M2cFp6D3BRbSd4rBFnJs-UxFBBG-CDWIoxP38tUYq5UNuY5mgQoQcsfQ].
A combination of patient-reported subjective cognitive impairment and measurable clinical symptoms, such as amyloid-beta accumulation in the cerebrospinal fluid, may help in the early diagnosis of Alzheimer’s disease. Subjective memory disorders in conjunction with conspicuous levels of beta-amyloid proteins in the cerebrospinal fluid are a strong indication of developing Alzheimer’s disease. This is the conclusion of a DZNE study involving about 1,000 older adults. [Retrieved from https://neurosciencenews.com/feeling-measure-alzheimers-20581/].
***Ask me about the dorsal raphe nucleus at the brainstem, TDP-43 (FTLD–TDP) folding proteins, beta-amyloid plaque build-up, Dkki-1 at the midbrain stem, prefrontal cortex and the frontal lobe for Alzheimer’s (dyslexia as well). Also ask me about the RAS-conscious around the age of three, ARAS and God awareness age 21–25 (Petty, Peter G. “Consciousness.” Journal of Clinical Neuroscience, vol. 3, no. 4, 1996, p. 390., doi:10.1016/s0967-5868(96)9004.
“Young children who are neglected or maltreated have abnormal patterns of cortisol production. Also, a family’s experience of economic hardship is associated with elevated cortisol levels among children. A mother’s depression during her child’s early years can lead to even higher cortisol levels. Under such conditions, the child becomes more vulnerable to a range of stress-related disorders affecting both mental health (e.g., depression, anxiety disorders, alcoholism, drug abuse) and physical health (e.g., cardiovascular disease, diabetes, stroke).” Also, in the early years, Comfort seeking may be difficult for people with intellectual or multiple disabilities, because they are often less securely attached or they lack the behaviors to seek comfort. In general, the experience of stress, coping with stress, attachment behaviors and disabilities seem to be closely related in this population (Janssen et al., 2002; Schuengel and Janssen, 2006; Schuengel et al., 2013; Giltaij et al., 2016). [Retrieved from https://neurosciencenews-com.cdn.ampproject.org/c/s/neurosciencenews.com/alzheimers-progression-19565/amp/?fbclid=IwAR1A1JkYfAouT5rwApfIN27RLWYlB3XO5T5go_pw6EDH4d8PCTgpN8gws3U; https://www.gse.harvard.edu/news/uk/08/05/stress-levels-and-developing-brain?fbclid=IwAR3dbxQa6noieCc9agDesnleGc3wg24YPc3gNHgi1gug5J06WHwNmRCHrsk#.YIbY-LbnnmY.twitter%20C; https://www.frontiersin.org/articles/10.3389/feduc.2020.540387/full].
Pineal Body, Pituitary & Adrenal Glands (see hypothalamus below)- synthesizes hormones such as our melatonin, serotonin, and dopamine and cortisol which helps you respond to stress (reading for example) and has many other important functions. Acetylcholine and dopamine are the bridge of the synaptic gap between neurones, are the ‘neurotransmitters in mind’ that form the substance of the volume, which is essential for consciousness. Also melatonin studies recently show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity.
Note: Students with (anger) Sympathetic Functional System Dominance (SFD) are deficient in dopamine, melatonin, and have hyer-norepinephrine production (diligence- fight, flight, flee & hyperarousal). Students with (shame) Parasympathetic Functional System Dominance (PFD) are deficient in serotonin, melatonin, and have hypo-norepinephrine production (hypoarousal, memory retrieval, diligence/motivation-freeze). Note: The pineal gland helps with a meditative state if the head is covered- it’s great for Calm (I will write more about calm ahead! Varied is, of course, Total Functional System Dominance (TFD) which is most varied in hormones and the hardest time being calm with mood swings along gaining equanimity also can be diagnosed congenital adrenal hyperplasia. [Retrieved Singleton, Omar, et al. “Change in Brain stem Gray Matter Concentration Following a Mindfulness-Based Intervention Is Correlated with Improvement in Psychological Well-Being.” Frontiers in Human Neuroscience, Frontiers Media S.A., 18 Feb. 2014].
Is there a worry gene? Yes… Silence this BDNF gene (common with OCD, Anxiety, Depression) doing the above activities. Researchers at Yale have identified a gene mutation for “rumination” — the kind of chronic worry in which people obsess over negative thoughts. It’s a variation of a gene known as BDNF that’s active in the hippocampus, an area of the brain involved in thinking and memory. Retrieved from https://www.wsj.com/articles/SB120035992325490045
Bianca Jones Marlin, PhD, a neuroscientist and assistant professor of psychology at Columbia University, found that mice that had given birth are more likely to pick up crying pups than virgin animals and that the oxytocin released during the birth and parenting process actually changes the hearing centers of the brain to motivate prosocial and survival behaviors. Most importantly, The social hormone oxytocin also plays a role in facilitating empathy.(Retrieved from https://www.apa.org/monitor/2021/11/feature-cultivating-empathy?fbclid=IwAR2pz_TBwefQbmTUxg3XPiNfoXe-F8480VMpDH1c6KgpDtk3L552fDoTsaM; Nature, Vol. 520, No. 7548, 2015).
Researchers propose a new framework for three seemingly unconnected forms of creativity.
Creativity is understood as the creation of novel, useful and surprising solutions.
The researchers argue that the associated cognitive processes, such as the ability to abstract, improvise, or think divergently, involve different brain areas that are interconnected. These areas include the cerebellum, hippocampus, prefrontal cortex, and basal ganglia.
Different areas are activated depending on the type of creativity. The similarities and differences between these types of creativity and their neuronal circuits are described by the model with the help of algorithms. [Retrieved from https://neurosciencenews.com/neurobiology-creativity-20723/]
Come to Him (Power)- Humbled by His Honor for: He might be the Lord of both the dead and the living. ‘ (Romans) 14:9 In Christ to “Let it go, [and know] this too shall pass” 2 Corinthians 4: 17-18…God, Abba please send The Teacher for Goodness and The Comforter to her now…thank you, God.
Humbled by His Honor for: ‘And hope does not put us to shame, because God’s love has been poured out into our hearts through the Holy Spirit, who has been given to us. ‘ (Romans 5:5) ‘Let every soul be subject unto the higher powers. For there is no power but of God: the powers that be are ordained of God. ‘ Romans 13:1
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AVOID SHAME– ASUNETOS (Strong’s #801 — Adjective — asunetos — as-oon’-ay-tos ) “without understanding or discernment” (a, negative, sunetos, “intelligent, understanding”), is translated without understanding” in Matthew 15:16 : Mark 7:18; Romans 1:31; 10:19 , RV, “void of understanding” (AV, “foolish”); in Romans 1:21 , RV, “senseless” (AV, “foolish”).
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‘Now to Him who is able to keep you from stumbling or falling into sin, and to present you unblemished [blameless without shame) and faultless (pure of heart)] in the presence of His glory with triumphant joy and unspeakable delight, to the only God our Savior, through Jesus Christ our Lord, be glory, majesty, dominion, and power, before all time and now and forever. Amen.’ Jude 1:24-25
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